David Greenberg, MD, PhD, Professor

Vascular and neuronal mechanisms in stroke

Dr. Greenberg studies the normal responses that help protect or repair the brain after a stroke.  He hopes to open the door to new treatments that can mimic those beneficial reactions.   Stroke results when the flow of blood to the brain is interrupted.   The body responds by boosting the production of proteins that help cells to survive or tissues to regenerate. The Greenberg lab is exploring the actions of two protective proteins, neuroglobin and VEGF, or vascular endothelial growth factor.

Dr. Greenberg has also pursued one of the most encouraging recent discoveries in neurobiology. New nerve cells can be born in the adult brains of mammals, a finding that corrected a long-held theory that dead nerve cells could never be replaced. Dr. Greenberg has shown that new neurons can arise as a response to stroke, and his lab has identified factors that promote neurogenesis. He is also working with Buck colleagues on cell transplantation as a therapy for stroke.

Dr. Greenberg received his MD and PhD from the Johns Hopkins University School of Medicine. He trained in internal medicine at New York Hospital-Cornell University Medical Center and in neurology at the University of California, San Francisco. He served on the faculty of the Department of Neurology at the University of California, San Francisco and the University of Pittsburgh before joining the Buck Institute in 1999. He serves as Vice President for Special Research Programs at the Institute.

Media Expertise
Dr. Greenberg welcomes media inquiries on the following subjects:
Stroke, neurogenesis, regenerative medicine and stroke.

dgreenberg@buckinstitute.org
Phone: 415-209-2087
Administrative Lab Coordinator: Rowena Abulencia
rabulencia@buckinstitute.org
Phone: 415-209-2206

“We hope to identify new approaches for treating stroke.’’

- David Greenberg, MD, PhD

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Recent Publications

2014

David A Greenberg, ... David A Greenberg "Cerebral angiogenesis: a realistic therapy for ischemic disease?" Methods Mol. Biol. 1135 21-4
Xiaoou Mao, Lin Xie... David A Greenberg "LOX-1 expression and oxidized LDL uptake and toxicity in the HN33 neuronal cell line." Neurosci. Lett. Epub ahead of print
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